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Elevated expression of Aurora A and B frequently
2024-04-26
Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali
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Recruitment of the Rad BP
2024-04-26
Recruitment of the Rad9/53BP1 mediator to AP1903 involves multiple pathways (Fig. 2). In unperturbed conditions, Rad9 is already bound to chromatin via interaction between its Tudor domain and methylated histone H3 at lysine 79 [82], [83], [84], [85]. This constitutive Rad9 recruitment to chromatin
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According to the diversity in molecular skeletons aromatase
2024-04-26
According to the Erteberel in molecular skeletons, aromatase inhibitors can be categorized into two types: steroidal and non-steroidal blockers [6]. Steroidal AI (e.g., exemestane in Fig. 1) derived from the substrate androstenedione interacts with aromatase through chemical actions, resulting in a
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br The role of apelin in respiratory diseases At
2024-04-26
The role of apelin in respiratory diseases At present, several scientific studies have suggested that the apelin/APJ system may play an important role in the development of pulmonary diseases (Table 4). For example, in an experiment on rats suffering from acute lung injury, apelin-13 decreases th
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In spite of this unexpectedly after three week
2024-04-26
In spite of this, unexpectedly, after three-week cherry puree consumption no AC increase was observed, irrespective of the method used (Table 2). A statistically significant decrease of AC was even measured by LOX-FL and ORAC methods (−3.5% and −9%, respectively). Nevertheless, a much more evident d
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Further evidence for action mechanism was provided by assays
2024-04-25
Further evidence for action mechanism was provided by assays using [3H]nisoxetine, a selective NET inhibitor used as standard radioligand for competitive binding experiments. The results showed dose-dependent blocking of [3H]nisoxetine binding by both xylazine and dexmedetomidine. Nisoxetine binds t
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parecoxib br Conclusion The HT receptor family is complex an
2024-04-25
Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless parecoxib (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function); molecular biology
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br New AMPK activators Fenofibrate is a drug of
2024-04-25
New AMPK activators Fenofibrate is a drug of the fibrate class used for the treatment of dyslipidemia [53] but is also an agent that could alleviate DN-induced alterations through AMPK activation (Fig. 2). Streptozotocin-induced diabetic rats treated with fenofibrate improved in not only renal fu
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Our published data showed that in mouse
2024-04-25
Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function
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In humans the major LOs are subdivided by their positional
2024-04-25
In humans, the major LOs are subdivided by their positional specificity into 5-(ALOX5), 12-(ALOX12) and 15-LO (ALOX15) (Kuhn et al., 2015). 5-LO is the key enzyme for LT biosynthesis and mainly found in mature cells from myeloid origin, including neutrophil, eosinophil and basophil granulocytes, mon
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Based on the observation that antipsychotic
2024-04-25
Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene
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The exact etiology of BPH is not completely
2024-04-25
The exact etiology of BPH is not completely understood, however this pathology has been associated with elevated meclofenamate levels of the androgen DHT (10). Thus, a valuable strategy in BHP treatment is the reduction of DHT (10) levels, by inhibiting its biosynthetic production [6], [8]. An impo
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Exposure to cisplatin with ATR
2024-04-25
Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre
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br Author contributions br Conflicts
2024-04-25
Author contributions Conflicts of interest The authors declare no competing financial interests. Acknowledgement This work was supported by grants from the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich/Transregio 166–Project C1 and grant CA 1014/1-1 to D.C.) and the IZKF Würzbur
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Another heroic set of studies combining
2024-04-25
Another heroic set of studies combining retrodialysis with electrophysiological recording at two distinct brain sites further indicated that the estradiol-induced increase in auditory-evoked firing in NCM also enhanced the selectivity of auditory-evoked responses in the downstream sensorimotor nucle