• br Resource table br Resource details Multiple endocrine

  2018-10-24

  

  Resource table Resource details Multiple endocrine neoplasia type 1 (MEN1) (also termed Wermer syndrome) is an autosomal dominant hereditary which is caused by mutations on the tumor suppressor gene MEN1. MEN1 is characterized by tumorigenesis mainly in endocrine organs including parathyroid g

• With these results we provide evidence that

  2018-10-24

  

  With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro

• Increased DA secretion from SZ hiPSC neurons is consistent w

  2018-10-24

  

  Increased DA secretion from SZ hiPSC neurons is consistent with the ability of current antipsychotics, functioning as D2 DA receptor antagonists, to ameliorate the positive symptoms of SZ (Seeman, 1987; Coyle and Konopask, 2012; Eyles et al., 2012). Interestingly, because current antipsychotics lack

• Potential sources of NSCs include cell lines pluripotent

  2018-10-24

  

  Potential sources of NSCs include cell lines, pluripotent stem cell-derived NSCs, and primary NSCs harvested from fetal or adult animals. Some immortalized NSC lines can engraft and migrate extensively (Snyder et al., 1995), but they may have unstable genomes or pose a risk of tumorigenesis (Koso et

• Mechanisms underlying CIPN include direct and indirect

  2018-10-24

  

  Mechanisms underlying CIPN include direct and indirect effects on sensory nerves such as damage to neuronal cell bodies in the dorsal root ganglion, alteration of the amplitude of the sglt or conduction velocity (Argyriou et al., 2012; Sisignano et al., 2014). Whereas CIPN may be reversible for som

• Overall our robust transcriptome data in cells undergoing hi

  2018-10-24

  

  Overall, our robust transcriptome data in pdgfr undergoing hiPSC reprogramming showed dramatic changes in cell signaling pathways, human-specific AS, and ASE during the progressive cell fate change of fibroblasts to iPSCs (Figure 6E). The data will broaden the knowledge of the reprogramming process

• Importantly STS and STS have been shown to have overlapping

  2018-10-24

  

  Importantly, STS1 and STS2 have been shown to have overlapping functions (Carpino et al., 2002; Carpino et al., 2004). However, although expansion of LSK, increased serial colony growth, and hyperphosphorylation of FLT3 were largely attributable to the loss of STS1, further loss of STS2 strengthened

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank Y. Sasai (RIKEN, Japan) for the RAX-GFP mESC line, M. Wegner (University of Erlangen, Germany) for SOX9, E. Tanaka (CRTD, Germany) for RAX and CRX, and D. Forrest (NIDDK, USA) for TRβ2 antibodies. We thank J. Brzezinski (

• qRT PCR showed that the expression of the PRC core

  2018-10-24

  

  qRT-PCR showed that the expression of the PRC2 core components Ezh2, Suz12, and Eed was not reduced upon Dicer deletion (Figure 2A). Similarly immunoblotting showed no reduction of EZH2, SUZ12, or JARID2 proteins or global H3K4me3 or H3K27me3 (Figure 2B). Cellular fractionation experiments confirmed

• The naive to lineage primed transition

  2018-10-24

  

  The naive to lineage primed transition was proposed as a gradual continuum of pluripotent states with distinct functional and transcriptional signatures and biases (Tesar, 2016). Several stem cell types with different degrees of pluripotency can be established under artificial culture conditions (Wu

• br As this takes place we

  2018-10-24

  

  As this takes place, we have an easily testable relation meaning that it does not particularly matter in which order the independent regressors and the independent response components are lined when takes the diagonal form. With the OLS estimate and the mutual covariance matrix of the vector co

• In addition stigma experienced by the study participants can

  2018-10-24

  

  In addition, stigma experienced by the study participants can explain the low rate and inverse effect of purchase AKT inhibitor VIII participation. Stigma against PLWH is a known barrier to accessing HIV testing and care. Perceived stigma negatively affects the quality of life (QoL) of PLWH (Holze

• Besides playing a role in platelet aggregation Chang et

  2018-10-23

  

  Besides playing a role in platelet aggregation (Chang et al., 2010; Kerrigan et al., 2009; Mourao-Sa et al., 2011), a function for CLEC2 on other immune over here has yet to be defined. Here we show that soluble CLEC2 regulates Kupffer cell polarization in the liver and improves glucose and lipid p

• br Materials and Methods br Results

  2018-10-23

  

  Materials and Methods Results Discussion Our work was inspired by the classic observation that the intradermal injection of a suspension of granulomatous splenic tissue (Kveim–Siltzbach test) induces granuloma formation weeks later in patients with sarcoidosis, suggesting the presence of an

• discover this Aspirin acetylsalicylic acid belongs to the

  2018-10-23

  

  Aspirin (acetylsalicylic acid) belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs) which share common therapeutic and side-effects through the inhibition of COX-1 and COX-2 (). Aspirin is the only NSAID which causes an irreversible inactivation of COX-isozymes through acetylation

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