• Further extensive FISH and molecular studies

  2019-06-13

  

  Further extensive FISH and molecular studies failed to detect either BCR–ABL, PDGFRA, PDGFRB and FGFR1 rearrangements or NPM1 and FLT3 mutations, whereas c-KIT D816V hiv fusion inhibitors was found on PB and BM mononuclear cells. Moreover, allele-specific PCR demonstrated JAK2 V617F mutation on bot

• br Genetic basis Similar to other arrhythmia

  2019-06-12

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• br Case report We report a case

  2019-06-12

  

  Case report We report a case of an 18 year-old Caucasian male who was found to have thrombocytopenia at birth, with a platelet count of 58,000/mm3. Bone marrow biopsy was first performed in 1993, at 13 months of age, and showed 70–80% cellular marrow with occasional megakaryocytes and no evidence

• br The slow progress in endemicity mapping of

  2019-06-12

  

  The slow progress in endemicity mapping of neglected tropical diseases (NTDs) in Africa and scaling up of mass drug administration (MDA) in all endemic countries has hampered efforts to meet the London 2020 elimination and control targets. Lymphatic filariasis is targeted to be eliminated by 2020

• This population based study demonstrates that interventions

  2019-06-12

  

  This population-based study demonstrates that interventions must change attitudes regarding violence in the home and society, promote positive parenting practices, and tackle the inequality that allows the normalisation of violence and patriarchal power over women and children. Violence does not occ

• This study was supported by the Ministry of Education Scienc

  2019-06-12

  

  This study was supported by the Ministry of Education, Science and Technological Development of Serbia (grant# 175083). Introduction In the United States, PCa was the most commonly found cancer among all males, according to the US Centers for Disease Control and Prevention (CDC). In Taiwan, PCa

• We also looked at antithrombotic therapy for

  2019-06-12

  

  We also looked at antithrombotic therapy for each CHADS2 score in each country. For patients with CHADS2 score of (Fig. 3), approximately 80% of the physicians used antiplatelet agents in 6 of the countries—Australia, China, Korea, Taiwan, Hong Kong, and Singapore. A total of 59% of the physicians u

• br A KCNJ mutation corresponding to an S L mutation

  2019-06-12

  

  A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6

• Preference for injectable therapy over

  2019-06-12

  

  Preference for injectable therapy over oral therapy [17], contrary to our findings from a previous study [18], could reflect the fact that most patients have not received an oral bone-targeted agent for metastatic disease. However, the practical advantages of an injectable therapy and the lack of ne

• Introduction Lung cancer is the most

  2019-06-12

  

  Introduction Lung cancer is the most common and deadly malignancy in Taiwan, the cause of an estimated 33,919 new cases between 2002 and 2008. Although the 5-year survival rate is only 15.9%, the overall survival rate is as high as 60.7% in patients whose tumors are confined to the primary site at

• In the past decade preclinical studies have

  2019-06-12

  

  In the past decade, preclinical studies have addressed the putative role of non-coding RNAs in tumorigenesis, metastasis and therapy response in osteotropic cancers. Besides long non-coding RNAs, microRNAs (miRs) represent a class of small non-coding RNAs, (18–25 nucleotides long), that regulate pro

• Respecto a la ideolog a que ostent en los a

  2019-06-12

  

  Respecto dna synthesis inhibitors la ideología que ostentó en los años ochenta, temporalidad en que fue ajusticiado el coronel Máximo Zepeda, podemos decir que ésta se fue matizando durante su larga trayectoria periodística hasta su decadencia financiera y posterior desaparición, la que fue examinad

• The renin angiotensin system plays a crucial

  2019-06-11

  

  The renin-angiotensin system plays a crucial role in atrial fibrosis, which is a key pathological consequence of AF. Genes encoding 3 molecules related to the renin-angiotensin system, including angiotensin-converting enzyme (ACE), angiotensinogen, and angiotensin type 1 receptor (AT1R), are associ

• br Conflict of interest br Case presentation A

  2019-06-11

  

  Conflict of interest Case presentation A 64-year-old female presented to the emergency room with persistent dizziness that began early that morning. She had a 30-year history of palpitations and known electrocardiogram (ECG) abnormalities. Her pulse was irregular at 130–270min−1 and blood pres

• The increasing burden of NCDs

  2019-06-11

  

  The increasing burden of NCDs poses an enormous threat to populations and health systems across the globe. The Sustainable Development Goals represent an important opportunity to integrate efforts to reduce the burden of NCDs and promote sustainable development. The recent identification of NCDs as

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