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Pahlavanzadeh and Fakouri Baygi employed PC SAFT
2020-09-15
Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the IFN-gamma, murine recombinant receptor of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that
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A similar pattern was observed for
2020-09-15
A similar pattern was observed for both tissues of P. harpagos, evidencing the absolute predominance of acetylcholinesterase. As observed, no effects were attributed to Iso-OMPA. The hypothesis that the major cholinesterasic form is AChE was reinforced considering the higher hydrolytic activity, whi
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Agarose GPG/ME mg In addition to carbamates organophosphates
2020-09-15
In addition to carbamates, organophosphates are classic inhibitors of cholinesterases. Previous studies with aquatic organisms have demonstrated their sensitivity to such chemicals. For example, individuals of the freshwater fish Colossoma macropomum exposed to the organophosphate dichlorvos, chlorp
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SS is a high grade
2020-09-15
SS is a high-grade malignant soft tissue sarcoma accounting for 5%–10% of soft tissue sarcomas. After RMS, SS is the most common sarcoma in children, adolescents and young adults [9]. SS originates primarily in the lower (62%) and upper (21%) extremities but may occur at any anatomic site [9], [10].
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br Results br Discussion Adaptive drug resistance is a major
2020-09-15
Results Discussion Adaptive drug resistance is a major challenge to the clinical success of cancer therapies. Incomplete inhibition of oncogenic signaling allows survival of “drug-tolerant” tumor cells, which persist in that state for variable periods before acquiring additional genetic mutati
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ACAT may act as a dimer of
2020-09-15
ACAT1 may act as a dimer of dimer [38]. Within each dimer, it may contain two identical sterol substrate sites (designated as site S), and one or two sterol activator site(s) (designated as site A). Site S preferentially binds pregnenolone (PREG); it can also bind a variety of sterols that contain 3
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br Cytochrome P monooxygenases Cytochrome P monooxygenases P
2020-09-15
Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o
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Many studies have documented that enolase acts as a plasmino
2020-09-15
Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor
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Recently a non proteolytic role of COP in stabilizing
2020-09-14
Recently, a non-proteolytic role of COP1 in stabilizing PIF3 proteins in the dark has been revealed . Previous studies have shown that the endogenous levels of PIF3 protein in etiolated seedlings were nearly undetectable . Ling found that the GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2) p
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A range of inhibitors were
2020-09-14
A range of inhibitors were therefore synthesized containing either carboxylic BAY 61-3606 or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respectively (). Analysis
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br Introduction Plasmodium falciparum malaria continues
2020-09-14
Introduction Plasmodium falciparum malaria continues to be a major global cause of mortality and morbidity. Malaria treatment and control has been complicated by the emergence of resistance to widespread antimalarial drug use. The most common method for measuring antimalarial resistance is estima
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Saururus chinensis Lour Baill Saururaceae
2020-09-14
Saururus chinensis (Lour.) Baill. (Saururaceae), a perennial herb, is widely cultivated in China and southern Korea. It has been traditionally used as folk medicine for the treatment of inflammation, jaundice and gonorrhea [8]. Previous chemical studies of S. chinensis have revealed the presence of
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Multiple sequence alignment of the proteins in the
2020-09-14
Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino nrf2 keap1 residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved residues, are found in a loop on th
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We also determined the uracil content of CJ
2020-09-14
We also determined the uracil content of CJ236 DNA by thin-layer chromatography of in vivo32P- or [6-3H]uracil-labeled CJ236 2′-deoxyribose 5′-monophosphates as well as by LC/MS of deoxyuridine and thymidine 2′-deoxynucleosides (Table 1, Table 2, Table 3). Examination of the 32P data showed that, ba
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Widely expressed mammalian adhesion receptors for fibrillar
2020-09-14
Widely expressed mammalian adhesion receptors for fibrillar collagens include the α2β1- and α11β1-integrins and the discoidin domain receptors (DDRs), DDR1 and DDR2 (Leitinger, 2011). Integrins and DDRs bind distinct and separate motifs in native fibrillar collagen (Curat et al., 2001, Vogel et al.,
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