• In recent large clinical studies AIM

  2021-09-13

  

  In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic (R)-(-)-Niguldipine hydrochloride to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH stu

• br Methods br Results br Discussion Significant alterations

  2021-09-13

  

  Methods Results Discussion Significant alterations in the expression of genes related to the glutamatergic system have been shown in several experimental models of epilepsy; however, in most studies focused on acute changes or modifications in expression, these were investigated during the

• Introduction l Glutamate is a

  2021-09-13

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

• br Declaration of interest br Acknowledgments This work was

  2021-09-13

  

  Declaration of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 31471615), the Introduction of Talent Research Start-up Fund of Anhui Polytechnic University (No. 2017YQQ017) and the Pre-research Project of National Natural Sc

• Recently several studies addressed cytological and biochemic

  2021-09-13

  

  Recently, several studies addressed cytological and biochemical features of oocyte aging. It was reported that cytological changes associated with the mammalian post-ovulatory oocyte aging include chromatin disorganization, abnormal meiotic spindle location or its disruption, partial exocytosis of c

• br Medium to long chain fatty acids Medium to long

  2021-09-13

  

  Medium- to long-chain fatty acids Medium- to long-chain fatty acids impart a wide range of physiological effects. Medium-chain and long-chain fatty acids have 6–12 carbons and >12 carbons, respectively. As the energy source, these fatty acids are supplied primarily by food intake, biosynthesis, a

• br Conflict of interest br Acknowledgments The

  2021-09-13

  

  Conflict of interest Acknowledgments The research was funded by the Major Programs of Pharmaceutical research project of Jiangsu Province (Q2018044). Introduction Lipids are important regulators of cell death. In mammalian cells, both apoptotic and non-apoptotic cell death pathways can be

• Accordingly and in animal models a

  2021-09-13

  

  Accordingly and in animal models, a high-fat diet rich in CO (CO-HFD) impeded ventricular function and induced cardiac cell death and remodeling, at least, by down-regulating cell antioxidant defense systems and induction of oxidative stress [28], [29], [30], [31]. Interestingly, long chain fatty ac

• Here we showed that microinjection of siRNA

  2021-09-13

  

  Here we showed that microinjection of siRNA at the MII stage efficiently reduced endogenous EZH2 mRNA and protein. Although the percentage of cleaving embryos was not affected, N-Acetylneuraminic acid mg formation and blastocyst cell number were both reduced in EZH2 knockdown groups (Table 1). Simi

• br Acknowledgement This research was supported by Basic Scie

  2021-09-13

  

  Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1A2B4012818). Oral DPQ is the most popular administration route due to good patients’ complianc

• Liposomes that are less than nm in diameter are

  2021-09-13

  

  Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by BAY 87-2243 (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even smaller diameters a

• All HFD fed groups in our study having

  2021-09-11

  

  All HFD fed groups in our study, having significantly higher levels of EE (heat production) is consistent with previous studies [91], where a significant increase in EE was observed within just one week of HFD feeding [81]. It is hypothesized that this phenomenon is due to the increased body mass an

• Molecular modeling studies also revealed insignificant

  2021-09-11

  

  Molecular modeling studies also revealed insignificant differences in ligand-receptor interaction energies between R and S enantiomers of LPCs or their 2-OMe-analogues, suggesting that enantiomers of a particular structure should exert similar GPR119-mediated biological effect. Indeed, when studied

• To determine the functional consequences

  2021-09-11

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• br The methyl aspartate receptor NMDAr hypofunction hypothes

  2021-09-11

  

  The -methyl--aspartate receptor (NMDAr) hypofunction hypothesis of schizophrenia correlates disease symptomology with glutamatergic neurotransmission dysfunction., , , Therefore, inhibition of glycine transporter 1 (GlyT1) to elevate synaptic levels of glycine and potentiate NMDAr signaling is a

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