• FRAP assay measures the reducing

  2018-10-22

  

  FRAP assay measures the reducing ability of antioxidants against oxidative effects of reactive oxygen species. The antioxidant potential is estimated by ability of anti-oxidants to reduce TPRZ-Fe (III) complex to TPTZ-Fe (II). Total antioxidant power may be considered analogous to total reducing pow

• As expected there was a significant upregulation of early

  2018-10-22

  

  As expected, there was a significant upregulation of early and late lineage-specific genes during hHF-MSCs differentiation. Smooth muscle specific genes such as α-SMA, SM22 and myocardin were upregulated significantly during myogenic induction. Interestingly, GDC-0941 of myocardin displayed a perio

• Since topography of our lesion includes cortical and sub cor

  2018-10-22

  

  Since topography of our lesion includes cortical and sub-cortical areas, motor impairments of limb functioning and placing deficits were evaluated in the present study by foot fault test which has commonly been used as an efficient and sensitive test strategy for chronic assessment of skilled fore-

• We found that systemic DXP immunosuppression was less succes

  2018-10-22

  

  We found that systemic DXP immunosuppression was less successful than local administration of TCA but view the translational value of these findings cautiously. Little is known about differences in immune rejection between RPE xenografts, as done here, and allografts as contemplated in patients. To

• It has been previously confirmed that

  2018-10-22

  

  It has been previously confirmed that SB-505124 selectively inhibits TGF-β and activin signaling more efficiently than its analog SB-431542 (DaCosta Byfield et al., 2004), which has been shown to induce neural differentiation when used in combination with Noggin (Chambers et al., 2009). IWP-2, on th

• To better characterize the Carnegie stage primate PGCs

  2018-10-22

  

  To better characterize the Carnegie stage 23 primate PGCs, we performed immunofluorescence for the basement membrane protein Laminin and the PGC marker OCT4 (Figure 2A). All OCT4-positive PGCs were located within the Laminin-positive cords in the testicular cortex at this age. We also discovered tha

• A paradoxical outcome of dietary SPI exposure is

  2018-10-22

  

  A paradoxical outcome of dietary SPI exposure is the shorter latency of Wnt1-generated mammary tumors, despite the significant reduction in tumor incidence in SPI-fed mice. We previously reported that in female rats exposed to SPI and administered with the direct acting carcinogen N-methyl-nitrosour

• KRAB associated protein KAP also known as TRIM and TIF

  2018-10-22

  

  KRAB-associated protein 1 (KAP1, also known as TRIM28 and TIF1β) is a novel Oct3/4-dependent transcription factor that regulates pluripotency (Seki et al., 2010). KAP1 was initially identified as an interaction partner of KRAB-domain containing zinc finger transcription factors (Friedman et al., 199

• The low efficiency of somatic cell reprogramming by the expr

  2018-10-20

  

  The low efficiency of somatic cell reprogramming by the expression of reprogramming factors delivered by viral vectors may be attributed to variations in transfection efficiency and transgene integration loci. Although the reprogramming efficiency significantly improved by drug-induced transgene exp

• In its effect on enhancing differentiation

  2018-10-20

  

  In its effect on enhancing differentiation of a large variety of human pluripotent stem cells, the effect of DMSO was thought to be mediated by causing an exit of the pluripotent cells from the cell cycle and greater effectiveness of differentiation factors in G1 (Chetty et al., 2013). However, in o

• br Conclusions The data presented

  2018-10-20

  

  Conclusions The data presented here demonstrate that MSX2 induces dedifferentiation with partial cell cycle re-entry in postmitotic multinucleated mammalian muscle cells. Our pharmacological treatment recapitulates MSX2-induced dedifferentiation and exhibits potential for future therapeutic proto

• The recent generation of iPS cells has brought

  2018-10-20

  

  The recent generation of iPS sodium salt has brought new hope to the field of regenerative medicine. Similar to ES cells, iPS cells are able to differentiate into all cell types of the three primary germ layers, which offers a unique approach for regenerative cell therapy (Takahashi and Yamanaka, 2

• Sca expression has earlier been shown to

  2018-10-20

  

  Sca-1 expression has earlier been shown to mark mCAP with poor CFE (Jensen et al., 2008; Jensen et al., 2009). We can now for the first time show that a PletA6Sca is a highly proliferative subpopulation of Plet-1pos cells that displays almost as efficient colony forming efficiency as A6, both in num

• br Experimental Procedures A detailed version

  2018-10-20

  

  Experimental Procedures A detailed version of our Experimental Procedures can be found in the Supplemental Experimental Procedures. All animal experiments were approved by the Danish Council for Supervision with Experimental Animals (#2011/561-1966). AR was performed at P1 as previously described

• Our results suggest several open questions that will require

  2018-10-20

  

  Our results suggest several open questions that will require further investigation. Although evidence suggests that eradication of cancer stem antifungal appears to be beneficial for curing cancers, recent studies also suggest that noncancer stem cells acquire a cancer stem cell phenotype when chal

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