• Loyo suggests that the construction of a

  2018-11-09

  

  Loyo (2006) suggests that the construction of a yield curve in the Brazilian financial system could become viable if the National Treasury issued long-term floating rate bonds, with higher returns, and in the meantime the Central Bank decreased the Selic rate, bringing more volatility to this rate.

• A 779 Strengths of this analysis include that the biomarker

  2018-11-09

  

  Strengths of this analysis include that the biomarker assay was analytically validated, the data were from a randomized clinical trial, and the hypothesis was prospectively stated prior to data unblinding (Khleif et al., 2010). The fact that a single biomarker was identified minimized the potential

• The essential autophagy gene beclin BECN is a haploinsuffici

  2018-11-09

  

  The essential autophagy gene beclin 1 (BECN1) is a haploinsufficient tumor suppressor (Liang et al., 1999; Qu et al., 2003; Yue et al., 2003) that is also located on the breast cancer tumor susceptibility chromosomal locus 17q21, ~150kb centromeric to BRCA1 (Aita et al., 1999). Monoallelic loss of B

• We identified two critical events that

  2018-11-09

  

  We identified two critical events that might be associated with pathomechanism collagen VI deficiency in our mice. The first event is a non-cell-autonomous effect from the collagen VI deficiency, causing the dysregulation in the number of myofibers in a muscle. In normal control mice, myofibers incr

• Chimera have been generated in

  2018-11-08

  

  Chimera have been generated in the lab exclusively as interspecific chimera between mouse species (Rossant and Frels, 1980) and recently rats (review by Iannaccone and Jacob, 2009). Even within the rodent family, intergeneric chimera between mice and voles did not succeed (Mystkowska, 1975a, 1975b).

• br Results br Discussion As the first step

  2018-11-08

  

  Results Discussion As the first step of our method, hiPS cells underwent differentiation into definitive endoderm by treatment with activin A and the GSK3β inhibitor CHIR99021. In other methods, activin A and Wnt 3a have mainly been used to induce definitive endoderm (D\'Amour et al., 2006; Kr

• Senexin B In the present study we used an in vitro model

  2018-11-08

  

  In the present study, we used an in vitro model system to observe the changes of phenotypic fate of astrocytes under different treatments. These data indicate that the elevation of Shh production in mechanically-insulted astrocytes plays a crucial role in the de-differentiation of astrocyte as Shh b

• Although in previous studies by Soldner et

  2018-11-08

  

  Although in previous studies by Soldner et al. (2011) and Ding et al. (2013), an initial FACS-based enrichment step of TALEN-expressing ibuprofen msds prior to subsequent PCR-based screening of this enriched cell population had to be included, both groups provided initial evidence that the footprin

• The gold standard for determining efficient HSPC homing

  2018-11-08

  

  The gold standard for determining efficient HSPC homing to bone marrow niches is their subsequent hematological reconstitution following transplantation in humans (Dahlberg et al., 2011; Ramirez et al., 2012), or, as surrogates, in immunodeficient mice or non-human primates (Goessling et al., 2011;

• In conclusion the present study utilized an in vivo

  2018-11-08

  

  In conclusion, the present study utilized an in vivo piglet model of hypoxic-preconditioning-induced ischemic tolerance to demonstrate that PC induces proliferation and neurogenesis of endogenous NSPs up to 7days after the hypoxic–ischemic insult. PC appears as a broad, non-invasive and reproducible

• Here we report that Dll counteracts the proliferation

  2018-11-08

  

  Here we report that Dll4 counteracts the proliferation of murine HPCs such as Lin−Sca+c-Kit+ (LSK) cells, by keeping a higher fraction of cells in the G0 state. This event was correlated with a downmodulation of some key salubrinal genes transcription such as D-CYCLINS. Furthermore, Dll4 limits the

• These conclusions rest mainly on three experimental facts a

  2018-11-08

  

  These conclusions rest mainly on three experimental facts: a model of myocardial injury with patent coronary circulation to test the spontaneous regenerative capacity of eCSCs; in situ labelling and genetic tracking the fate of c-kit positive cardiac stem mitoxantrone and the replacement of the eCS

• br Introduction Thyroid hormone TH is a critical

  2018-11-08

  

  Introduction Thyroid hormone (TH) is a critical regulator of many physiological and developmental processes, following its activation from the stable prohormone (l-thyroxine, T4) to the short-lived active hormone, triiodothyronine (3,5,3′-triiodo-l-thyronine, T3) (Fig. 1). T3 induces amphibian me

• Acknowledgments This work was supported by the

  2018-11-08

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank T

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion riPSCs are typically generated and cultured on MEF feeders (Liu et al., 2008). Feeders are sufficient to support rhesus iPSC long-term maintenance. However, this approach is too labor intensive for large-scale culture. Optimization of this culture sy

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