• Introduction Classically increased cardiac fibrosis

  2019-05-06

  

  Introduction Classically, increased cardiac fibrosis has been shown to be associated with altered cardiac conduction, causing conduction slowing, block, and reentry in studies on isolated animal and diseased human cardiac tissues [1–3]. Interestingly, similar findings were also demonstrated in isol

• br Methods We reviewed http www

  2019-05-06

  

  Methods We reviewed http://www.canadiancancertrials.ca/ and http://www.ontario.canadiancancertrials.ca/ in order to identify ongoing bone oncology-related trials. We used the keywords: bone, bone metastasis, bone treatment, cancer therapy induced bone loss and bisphosphonates for searching. We al

• Many studies over the past

  2019-05-06

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. Th

• br Materials and methods br Results We observed patterns

  2019-05-06

  

  Materials and methods Results We observed 3 patterns of response to PHP. Pattern 1, observed in 56% of patients (nos. 4, 6, 7, 8, and 9), was characterized by S–A and V–A intervals in the septal region that were identical whether HB was captured or not, along with an unchanged atrial activatio

• Pilsicainide might increase hERG proteins via

  2019-05-06

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• EPZ015666 manufacturer For many decades scientists have warn

  2019-05-06

  

  For many decades, scientists have warned that human activity is pushing life on our planet beyond the point of no return. In the Earth\'s history there have been five mass extinction events, most recently the Cretaceous–Tertiary mass extinction that occurred almost 65 million years ago and was thoug

• br Discussion The implant of a CRT device in a

  2019-05-06

  

  Discussion The implant of a CRT device in a patient with a resting ejection fraction of 50% represents off-guideline use of this therapy [1]. However, since the patient׳s significant NYHA Class III symptoms, LBBB and exertional ventricular dysfunction achieved evidence-based levels for improvemen

• One significant problem associated with

  2019-05-06

  

  One significant problem associated with chronic conditions is the lack of treatment persistence and compliance. It has been demonstrated that around 50% of patients suffering from such conditions discontinue their therapy early [10]. In the case of BC, older women are known to be at a higher risk of

• To date over mutations in KCNQ have been found to

  2019-05-06

  

  To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [

• Introduction Catheter ablation of accessory

  2019-05-06

  

  Introduction Catheter ablation of accessory pathways (APs) can be challenging depending on the location of the AP. Anteroseptal APs are rare but associated with lower success rates and higher incidence of atrioventricular (AV) block [1,2]. Data regarding the electrocardiographic and electrophysiolo

• Unfortunately no trends in retention in care

  2019-05-06

  

  Unfortunately, no trends in retention in care were presented by Nsanzimana and colleagues, and the method used to estimate life expectancy—the abridged life table method—is not well suited to answering questions about trends in quality of care, because it buy FLAG Peptide allows little scope for mu

• br Hasta donde yo s ese texto que

  2019-05-06

  

  Hasta donde yo sé, ese texto, que es una carta abierta “Au journal La Réforme”, es el único en La Tribune des Peuples que aparece firmado con el nombre de Bilbao. De ello se podría deducir que el joven exiliado chileno habría tenido un papel marginal en la empresa comandada por Mickiewicz. Pero el

• br We recently reported associations between

  2019-05-05

  

  We recently reported associations between maternal age at childbirth and outcomes in the offspring, using data from five birth cohorts (COHORTS collaboration) in low-income and middle-income countries (LMICs), in . Young maternal age ( Antimicrobial resistance is recognised as a serious global he

• br Discussion In the present case dyssynchronization

  2019-05-05

  

  Discussion In the present case, dyssynchronization between the atrial and ventricular beats resulted in abnormal pacing spikes detected on the surface electrocardiogram, and it is a potentially life-threatening condition. Previous case reports have suggested that this condition might be caused by

• Intimate partner violence is highly prevalent in

  2019-05-05

  

  Intimate partner violence is highly prevalent in sub-Saharan Africa and its role in increasing women\'s risk of HIV acquisition is well recognised, although many aspects of the mechanisms through which HIV increases women\'s risk remain unclear. The most important challenge for researchers is to de

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