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The acidification of endocytic compartments is closely relat
2023-12-15
The acidification of endocytic compartments is closely related to endocytic activity, although the mechanism linking acidification and membrane dynamics is largely unknown. In a recent RNA interference (RNAi)-based screen, V-ATPase depletion blocked the formation of clathrin-coated vesicles, an effe
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In conclusions MPE effects in causing
2023-12-15
In conclusions, MPE effects in causing lesser increase in vaginal fluid pH could partly restore the vaginal acidity in sex-steroid deficient state. MPE could exert its effect via enhancing both H+ generation as well as H+extrusion into the vaginal lumen. Although gallic Clozapine N-oxide is the mai
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This study evaluated the anti tumor influences of LA
2023-12-14
This study evaluated the anti-tumor influences of LA against HepG2 Sodium Picosulfate in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochond
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br Consequences of central apelin APJ modulation Regarding e
2023-12-14
Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs
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The studies have described that Candida non albicans
2023-12-14
The studies have described that Candida non-albicans are considered as remarkable pathogenic agents of OPC, and among them, C. tropicalis and C. glabrata are known as major strains that may replace C. albicans as the greatest causing agent of this infection [20], [21]. It has been shown that Candida
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br Conflict of interest statement
2023-12-14
Conflict of interest statement Introduction Currently, adenocarcinoma is the most common histological subtype of lung cancer. Activating mutations and translocations with a potential for targeted therapy are reported predominantly in non-smokers. ALK rearrangement is found in less than 5% of u
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br Disclosure br Acknowledgments br Introduction Deeper unde
2023-12-14
Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small pepstatin that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal g
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One study has demonstrated that PUFA
2023-12-14
One study has demonstrated that ω-3 PUFA reduced both cholesterol and caveolin-1 (a marker of raft), thereby displacing raft-associated signaling molecules from lipid raft [36]. Additionally, DHA treatment decreased the amount of lipid raft in the cell surface and displaced several lipid raft-associ
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and LO are members of the lipoxygenase family that convert
2023-12-13
5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic insulin receptor into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation of
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br Results and discussion In order to
2023-12-13
Results and discussion In order to investigate the assembly dynamics and aggregate structures of Aβ16-22, twelve molecular systems with the number of peptides varying from 1 to 12 were studied. In all simulations, the same peptide concentration (~15 mM) was maintained by adjusting the dimensions
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Because of the critical roles played by
2023-12-13
Because of the critical roles played by AMPK in energy sensing and cancer cell survival, a huge number of drugs have been proposed to exert their pharmacological effects by means of AMPK activation (Kim and He, 2013). For example, metformin has been shown to activate AMPK in muscle (Sajan et al., 20
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Here we provide evidence that NO contributes to
2023-12-13
Here, we provide evidence that NO contributes to changes in synaptic strength, but also offer an explanation as to why previous attempts to link NO to LTP have often failed. Our results describe a model by which cycling AMPARs, held in intracellular pools, are rapidly delivered to the membrane surfa
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We found that decreased Ng levels lead to a
2023-12-13
We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito
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br Results The newly synthesized leucine ureido derivatives
2023-12-13
Results The newly synthesized leucine ureido derivatives were firstly evaluated for their enzymatic inhibition using porcine kidney APN (Microsomal, Biocol) with bestatin as the positive control (Table 1). One isoleucine ureido derivative 14 and phenylglycine ureido derivative 15 were also synthe
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In the MT SGL two regularization parameters
2023-12-13
In the MT-SGL, two regularization parameters need to be specified: λ1 and λ2. Using recent results on norm regularization (Banerjee et al., 2014), it is possible to express both parameters via a single parameter as follows: and (Meier et al., 2008, Banerjee et al., 2014), where and are computed
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