KRAB associated protein KAP also known as TRIM and TIF

2018-10-22

KRAB-associated protein 1 (KAP1, also known as TRIM28 and TIF1β) is a novel Oct3/4-dependent transcription factor that regulates pluripotency (Seki et al., 2010). KAP1 was initially identified as an interaction partner of KRAB-domain containing zinc finger transcription factors (Friedman et al., 199

The low efficiency of somatic cell reprogramming by the expr

2018-10-20

The low efficiency of somatic cell reprogramming by the expression of reprogramming factors delivered by viral vectors may be attributed to variations in transfection efficiency and transgene integration loci. Although the reprogramming efficiency significantly improved by drug-induced transgene exp

In its effect on enhancing differentiation

2018-10-20

In its effect on enhancing differentiation of a large variety of human pluripotent stem cells, the effect of DMSO was thought to be mediated by causing an exit of the pluripotent cells from the cell cycle and greater effectiveness of differentiation factors in G1 (Chetty et al., 2013). However, in o

br Conclusions The data presented

2018-10-20

Conclusions The data presented here demonstrate that MSX2 induces dedifferentiation with partial cell cycle re-entry in postmitotic multinucleated mammalian muscle cells. Our pharmacological treatment recapitulates MSX2-induced dedifferentiation and exhibits potential for future therapeutic proto

The recent generation of iPS cells has brought

2018-10-20

The recent generation of iPS sodium salt has brought new hope to the field of regenerative medicine. Similar to ES cells, iPS cells are able to differentiate into all cell types of the three primary germ layers, which offers a unique approach for regenerative cell therapy (Takahashi and Yamanaka, 2

Sca expression has earlier been shown to

2018-10-20

Sca-1 expression has earlier been shown to mark mCAP with poor CFE (Jensen et al., 2008; Jensen et al., 2009). We can now for the first time show that a PletA6Sca is a highly proliferative subpopulation of Plet-1pos cells that displays almost as efficient colony forming efficiency as A6, both in num

br Experimental Procedures A detailed version

2018-10-20

Experimental Procedures A detailed version of our Experimental Procedures can be found in the Supplemental Experimental Procedures. All animal experiments were approved by the Danish Council for Supervision with Experimental Animals (#2011/561-1966). AR was performed at P1 as previously described

Our results suggest several open questions that will require

2018-10-20

Our results suggest several open questions that will require further investigation. Although evidence suggests that eradication of cancer stem antifungal appears to be beneficial for curing cancers, recent studies also suggest that noncancer stem cells acquire a cancer stem cell phenotype when chal

Introduction Cumulative lifetime hormone exposure as a resul

2018-10-20

Introduction Cumulative lifetime hormone exposure as a result of natural menstrual cycles and exogenous hormone therapies is a strong determinant of increased breast cancer risk. Progesterone, an ovarian steroid hormone that peaks during the luteal phase of the menstrual cycle, promotes the expansi

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Unlike the human prostate, which is organized into a single lobe with varying zonal layers, the murine prostate has four distinct lobes surrounding the urethra. The adult prostate contains three epithelial lineages

br Conclusion br Acknowledgements br

2018-10-20

Conclusion Acknowledgements Introduction Since the first successful reprogramming of somatic methysergide into induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka, 2006), countless efforts have been made to fully explore the potential applications of iPSCs in biomedical research

The majority of the characterized NETs bind

2018-10-20

The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem JNJ26481585 display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiation, wh

br Results br Discussion WNT proteins in vivo

2018-10-20

Results Discussion WNT proteins in vivo are often secreted locally and presented to responsive LY2228820 in a spatially controlled manner (Alexandre et al., 2014; Clevers et al., 2014; Farin et al., 2016; Goldstein et al., 2006; van den Heuvel et al., 1989). In this study, we present a covalen

Introduction The role of chromatin status on DNA

2018-10-20

Introduction The role of chromatin status on DNA damage response (DDR) and DNA double-strand break (DSB) repair has been extensively investigated in differentiated non-stem and cancer cells. Chromatin structure and remodeling plays an important role in the recruitment/assembly of repair factors and

Hello world!

2018-07-29