• In conclusion the present study utilized an in vivo

  2018-11-08

  

  In conclusion, the present study utilized an in vivo piglet model of hypoxic-preconditioning-induced ischemic tolerance to demonstrate that PC induces proliferation and neurogenesis of endogenous NSPs up to 7days after the hypoxic–ischemic insult. PC appears as a broad, non-invasive and reproducible

• Here we report that Dll counteracts the proliferation

  2018-11-08

  

  Here we report that Dll4 counteracts the proliferation of murine HPCs such as Lin−Sca+c-Kit+ (LSK) cells, by keeping a higher fraction of cells in the G0 state. This event was correlated with a downmodulation of some key salubrinal genes transcription such as D-CYCLINS. Furthermore, Dll4 limits the

• These conclusions rest mainly on three experimental facts a

  2018-11-08

  

  These conclusions rest mainly on three experimental facts: a model of myocardial injury with patent coronary circulation to test the spontaneous regenerative capacity of eCSCs; in situ labelling and genetic tracking the fate of c-kit positive cardiac stem mitoxantrone and the replacement of the eCS

• br Introduction Thyroid hormone TH is a critical

  2018-11-08

  

  Introduction Thyroid hormone (TH) is a critical regulator of many physiological and developmental processes, following its activation from the stable prohormone (l-thyroxine, T4) to the short-lived active hormone, triiodothyronine (3,5,3′-triiodo-l-thyronine, T3) (Fig. 1). T3 induces amphibian me

• Acknowledgments This work was supported by the

  2018-11-08

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank T

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion riPSCs are typically generated and cultured on MEF feeders (Liu et al., 2008). Feeders are sufficient to support rhesus iPSC long-term maintenance. However, this approach is too labor intensive for large-scale culture. Optimization of this culture sy

• br Materials and methods Information related

  2018-11-08

  

  Materials and methods Information related to Material and methods can be found in the Supplemental information section. Results Discussion We previously reported that O-GlcNAcylation is important in hESC commitment towards adipose and ectoderm lineages (Maury et al., 2013). However, O-GlcN

• By qPCR we confirmed that

  2018-11-08

  

  By qPCR we confirmed that DLL4 mRNA levels increase dramatically as the control shSCR cells undergo differentiation, but in shDLL4 cells the DLL4 mRNA is efficiently suppressed (Fig. 2E, left panel). To confirm that DLL4 mRNA suppression had a functional effect we analyzed the mRNA levels of two wel

• br Resource table br Resource details Urine

  2018-11-08

  

  Resource table Resource details Urine epithelial cells underwent the reprogramming procedure using the CytoTune®-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific, USA) containing reprogramming vectors with the four Yamanaka factors, Oct3/4, Sox2, Klf4 and c-Myc. These factors have be

• Endurance exercise training results in adipose

  2018-11-08

  

  Endurance exercise training results in adipose lipolysis and attenuation of fibrosis (Kawanishi et al., 2013a) and inflammation (Linden et al., 2014; Vieira et al., 2009) in adipose and skeletal muscle, independent of weight loss. Thus, participation in an endurance training program is a well-establ

• SATB acts as a master regulator by binding to genes

  2018-11-08

  

  SATB2 acts as a master regulator by binding to genes which regulate embryonic development, cell differentiation, pluripotency, and cell survival (Ordonez, 2014; Rosenfeld et al., 2009; Zhao et al., 2014). We have discovered the SATB2 kainate receptors in the promoters of c-Myc, Nanog, Kl4, Bcl-2 an

• br Acknowledgments br Introduction Expression of a defined

  2018-11-08

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• With these results we provide evidence that

  2018-11-08

  

  With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro

• In our static wells the average aggregate diameter was m

  2018-11-08

  

  In our static 12 wells, the average aggregate diameter was ∼210 μm, representing a relatively large spread of ∼100–400 μm in each well, typical of random aggregation. However, at 7.5 μM CHIR, JQ1 of all shapes and sizes differentiated into contracting, GFP+ EBs, whereas, at suboptimal CHIR concentr

• 4-ethylphenyl sulfate However before application in a clinic

  2018-11-08

  

  However before application in a clinical context, a number of issues still need to be considered. Indeed, SSC transplantation in cancer patients requires techniques to exclude cancer cell contamination, because implantation of as few as 20 leukemic 4-ethylphenyl sulfate can result in cancer relapse

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