• BGJ 398 The aim of our work was

  2019-05-28

  

  The aim of our work was not to advocate for performing LAA occlusion and AF ablation concomitantly. Indeed, given the potential benefits of a successful catheter ablation procedure for stroke BGJ 398 [3–5], some would appropriately advocate performing these procedures in a staged fashion. The aim of

• br Discussion The site of the successful ablation

  2019-05-27

  

  Discussion The site of the successful ablation was the earliest site where a TSP was recorded during tachycardia. The TSP preceded each His bundle deflection by 15ms during tachycardia, but was inverted during atrial pacing. Moreover, the TSP–His deflection interval remained unchanged at differen

• br Conflict of interest br Introduction br Baseline ablation

  2019-05-27

  

  Conflict of interest Introduction Baseline ablation strategies targeting PVs It is well known that PVI was first developed to eliminate the triggers that initiate attacks of paroxysmal atrial fibrillation [1]. Subsequently, the additional function of the PV myocardium to perpetuate atrial f

• It is established that hypoxia can

  2019-05-27

  

  It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 SAR405 after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections also indicates hy

• br Commentary Careful analysis of the

  2019-05-27

  

  Commentary Careful analysis of the electrocardiograph (Fig. 1) reveals narrow and similar QRS complexes in all the beats, showing that they are all intrinsic QRS complexes. Some intrinsic P waves are also visible at the ST-T segment (after R3, R7, R11, and R15); these are the beats without any sp

• Thomas Hoeksema por su parte explica la paradoja del t

  2019-05-27

  

  Thomas Hoeksema, por su parte, explica la paradoja del título del siguiente modo: “la destrucción (fuego) está moderada por la estabilidad y la armonía (reposo). La relación entre estas dos fuerzas es multidimensional y dialéctica”. Para Hoeksema, el segundo volumen poético de Pacheco se debe entend

• The review Bile acid receptor

  2019-05-27

  

  The review “Bile mps1 receptor link nutrient sensing to metabolic regulation” by Li and Li is focused on bile acid receptors in the regulation of hepatic glucose and lipid metabolism and inflammation. Cholestasis and NAFLD are inflammatory liver diseases. Triglycerides are non-toxic, but accumulati

• The National Family Health Survey of

  2019-05-27

  

  The National Family Health Survey of India emphasises the need to hydrate children who have diarrhoea, but there is no evidence to show that such an intervention in the home setting improves mortality. The eight out of ten practitioners who are unaware of childhood pneumonia symptoms in the developi

• In conclusion we demonstrated that cells with

  2019-05-27

  

  In conclusion, we demonstrated that ppar pathway with the standard Ph had no detectable BCR–ABL1 KD mutations and that they were responsive to imatinib therapy, while cells with the variant translocation harbored two KD mutations, a previously described one and a never previously reported one [5].

• To overcome these resistance mechanisms in APL cells

  2019-05-27

  

  To overcome these resistance mechanisms in APL cells, a number of drugs have been tested. Tamibarotene is approximately 10 times more potent than ATRA as an in vitro inducer of differentiation, and is chemically more stable than ATRA [5]. Although the precise mechanism of the combination of tamibaro

• ZIKV is a flavivirus related to dengue virus DENV and

  2019-05-27

  

  ZIKV is a flavivirus related to dengue virus (DENV) and historically has been transmitted by the same mosquito species, (). There is no available treatment or vaccine so disease control is limited to the management of mosquitoes which currently relies on either insecticides or the destruction of la

• br Discussion IUI with controlled ovarian hyperstimulation h

  2019-05-27

  

  Discussion IUI with controlled ovarian hyperstimulation has been used over the years as a treatment for mild male factor, anovulation, and unexplained infertility. It is less expensive and less invasive than other assisted reproductive techniques. Therefore, these advantages have made the techniq

• Although the CHADS score is useful for evaluating

  2019-05-27

  

  Although the CHADS2 score is useful for evaluating the risk of stroke in NVAF patients, about half of all NVAF patients have a score of or 1 [7]. There are no clear guidelines on whether warfarin should be administered or not, to these patients because the risk of annual incidence of stroke is so lo

• All patients with symptomatic cardiac AL amyloidosis

  2019-05-27

  

  All 4 patients with symptomatic cardiac AL amyloidosis had poor prognoses. The median survival period for these 4 patients was 12.3 months (minimum=4 months, maximum=28 months) (Table 1). The patient in Case 2, whose BNP level was the highest of the 4 patients, had the shortest survival period. Howe

• The study by Wan Ling Wong and colleagues

  2019-05-24

  

  The study by Wan Ling Wong and colleagues examines the overall prevalence of age-related macular degeneration. In agreement with previous studies, Wong and colleagues have projected that 196 million people will be affected by age-related macular degeneration in 2020, increasing to 288 million by 204

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